The ISL28270 and ISL28273 are dual channel micropower instrumentation amplifiers (in-amps) and the ISL28470 is a quad channel in-amp optimized for single supply operation over the +2. 4V to +5. 5V range. All three devices feature an Input Range Enhancement Circuit (IREC) which maintains CMRR performance for input voltages equal to the positive supply and down to 50mV above the negative supply rail. The input signal is capable of swinging above the positive supply rail and to 10mV above the negative supply with only a slight degradation of the CMRR performance. The output operation is rail-to-rail. The ISL28273 is compensated for a minimum gain of 10 or more. For higher gain applications, the ISL28270 and ISL28470 are compensated for a minimum gain of 100. The in-amps have bipolar input devices for best offset and excellent 1/f noise performance. The amplifiers can be operated from one lithium cell or two Ni-Cd batteries.