The ISL3232E, ISL4221E, and ISL4223E devices are 2. 7V to 5. 5V powered RS-232 transmitters/receivers that meet ElA/TIA-232 and V. 28/V. 24 specifications, even at VCC= 3. 0V. They provide ±15kV ESD protection (IEC61000-4-2 Air Gap and Human Body Model) on transmitter outputs and receiver inputs (RS-232 pins). Targeted applications are PDAs, Palmtops, and hand-held products where the low operational power consumption and even lower standby power consumption are critical. Efficient on-chip charge pumps, coupled with manual and automatic powerdown functions, reduce the standby supply current to a 150nA trickle. The 5mmx5mm Quad Flat No-Lead (QFN) packaging and the use of small, low value capacitors ensure board space savings. Data rates greater than 250kbps are ensured at worst case load conditions. The ISL4221E is a 1 driver, 1 receiver device and the ISL3232E and ISL4223E are 2 driver, 2 receiver devices that, coupled with the 5mmx5mm QFN package, provide the industry's smallest, lowest power serial port suitable for PDAs, and hand-held applications. The 5mmx5mm QFN requires 40% less board area than a 20 Ld TSSOP, and is nearly 20% thinner. The ISL4221E and ISL4223E versions feature an automatic powerdown function that powers down the on-chip power supply and driver circuits. Automatic powerdown occurs when an attached peripheral device is shut off or the RS-232 cable is removed, and conserves system power automatically without changes to the hardware or operating system. The ISL4221E and ISL4223E power back up automatically when a valid RS-232 voltage is applied to any receiver input.