The ISL3245xE are 3. 3V to 5V powered, fault protected, extended Common-Mode Range (CMR) differential transceivers for balanced communication. The RS-485 bus pins (driver outputs and receiver inputs) are protected against overvoltages up to ±60V, and against ±15kV ESD strikes. These transceivers operate in environments with common-mode voltages up to ±20V (exceeds the RS-485 requirement), making this RS-485 family one of the most robust on the market. The transmitters are RS-485 compliant with VCC≥ 4. 5V and deliver a 1. 1V differential output voltage into the RS-485 specified 54Ω load even with VCC= 3V. The receiver (Rx) inputs feature a full fail-safe design that ensures a logic-high Rx output if the Rx inputs are floating, shorted, or on a terminated but undriven (idle) bus. The Rx full fail-safe operation is maintained even when the Rx input polarity is switched (cable invert function on ISL32457E and ISL32459E). The ISL32457E and ISL32459E include a cable invert function that reverses the polarity of the Rx and Tx bus pins in case the cable is misconnected during installation.